BK viruria and viremia in children with systemic lupus erythematosus

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BK viruria and viremia in children with systemic lupus erythematosus

BACKGROUND BK virus (BKV) is a ubiquitous polyoma virus that lies dormant in the genitourinary tract once acquired in early childhood. In states of cellular immunodeficiency, the virus can reactivate to cause hemorrhagic cystitis and nephritis. Children with systemic lupus erythematosus (SLE) have an increased risk of developing infectious complications secondary to their immunocompromised stat...

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INTRODUCTION Human parvovirus B19 (PB19) is a single-stranded DNA virus that was first discovered in 1975 by Yvonne Cossart and her colleagues. It has been associated with a variety of clinical manifestations, including rash, thrombocytopenia, leukopenia, fetal wastage, hypocomplementemia, autoimmune hemolytic anemia, arthritis and vasculitis. It is the causative agent of erythema infectiosum (...

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BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia.

A role for polyomaviruses in the pathogenesis of systemic lupus erythematosus (SLE) has been suggested. BK virus (BKV) and JC virus (JCV) were demonstrated in single urine specimens from 7 (16%) of 44 and 5 (11%) of 44 patients with SLE and 0/88 and 18 (21%) of 88 matched healthy controls, respectively. During a 1-year follow-up study, episodes of polyomaviruria were detected in 16 (80%) of 20 ...

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Cutaneous Manifestations of Systemic Lupus Erythematosus in Iranian Children

Systemic lupus erythematous (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study was conducted to determine the pattern and prevalence of such lesions in SLE in Iranian children infected with SLE. Forty-eight patients, age between 3-16 yrs and male to female ratio of 7/1 were examined for the presence of cutaneous manifestations of SLE. The most co...

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ژورنال

عنوان ژورنال: Pediatric Rheumatology

سال: 2017

ISSN: 1546-0096

DOI: 10.1186/s12969-017-0156-2